Key result
Treatment with intravenous immunoglobulin and aspirin in a 24-day-old male with Neonatal Kawasaki disease resulted in a good prognosis with no carditis or coronary artery abnormalities at 1 year.
Why the study?
Kawasaki disease is extremely rare in neonates, motivating an exploration of its clinical features, diagnosis, and treatment for early identification.
Case Report (n=1)
Early diagnosis and treatment with IVIG and aspirin in neonatal Kawasaki disease can prevent coronary artery abnormalities and lead to a good prognosis.
May support considering KD in febrile neonates with rash; single case leaves diagnostic criteria open for validation.
RATIONALE: Kawasaki Disease (KD) is a self-limiting and acute systemic vasculitis of childhood that leads to coronary artery abnormality in about 25% of untreated cases. KD is extremely rare in neonates. The purpose of this paper is to explore the clinical features and diagnosis and treatment of Neonatal Kawasaki Disease for early identification. PATIENT CONCERNS: A 24-day-old male with 3 hours fever and a rash was admitted to our hospital. DIAGNOSES: He had a fever, rash, cracking of lips, lymph node enlargement in the neck, and distal extremity desquamation. INTERVENTIONS: The patient was given intravenous immunoglobulin and aspirin with no complications. OUTCOMES: After discharge, the patient was followed up to 1 year old, with good prognosis and no carditis or coronary artery abnormalities. LESSONS: Neonatal Kawasaki disease is extremely rare, and its clinical manifestation is not typical and easy to be missed. If not treated early, it will potentially give rise to coronary artery aneurysms or expansion, ischemic heart disease, and sudden death. Early diagnosis and treatment are very important.
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Li et al. (2021) conducted a case report in Neonatal Kawasaki disease (n=1). Intravenous immunoglobulin and aspirin was evaluated on Prognosis and coronary artery abnormalities. Treatment with intravenous immunoglobulin and aspirin in a 24-day-old male with Neonatal Kawasaki disease resulted in a good prognosis with no carditis or coronary artery abnormalities at 1 year.
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