Key result
A family history of Kawasaki disease was not associated with significantly different rates of IVIG resistance compared to no family history (8.3% vs. 22.1%, P=0.315).
Why the study?
Real-world outcomes of Kawasaki disease patients with a family history remain unclear in the era of 2 g/kg IVIG therapy.
Does a family history of Kawasaki disease affect the rates of IVIG resistance, coronary artery lesions, and recurrence in KD patients receiving acute-phase treatment?
Cohort (n=201)
Does a family history of Kawasaki disease affect the rates of IVIG resistance, coronary artery lesions, and recurrence in KD patients receiving acute-phase treatment?
In the era of 2 g/kg IVIG therapy, a family history of Kawasaki disease does not appear to significantly increase the risk of IVIG resistance, coronary artery lesions, or disease recurrence.
No outcome differences by family history in KD; leaves open whether prior epidemiological risks persist with 2 g/kg IVIG.
An epidemiological study showed that a positive family history of Kawasaki disease (KD) was a risk factor for intravenous immunoglobulin (IVIG) therapy resistance, coronary artery lesions (CALs), and KD recurrence. However, real-world outcomes of KD patients with a family history remain unclear. The objective of this study was to elucidate the outcomes of KD patients with a family history in the era of 2 g/kg IVIG therapy. This retrospective study included data from 201 KD patients who underwent acute-phase treatment from January 2009 to June 2020, with 184 (91.5%) receiving 2 g/kg IVIG therapy. The patients were divided into 13 (family group) with and 188 (nonfamily group) without a family history of KD. The rates of IVIG resistance (8.3% vs. 22.1%, P = 0.315), rescue therapy (8.3% vs. 12.8%, P = 1.000), CALs (0.0% vs. 2.7%, P = 1.000), and KD recurrence (0.0% vs. 3.2%, P = 1.000) were similar between the family and nonfamily groups.
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Toshimasa Nakada (2020) conducted a cohort in Kawasaki disease (n=201). Family history of Kawasaki disease vs. No family history of Kawasaki disease was evaluated on IVIG resistance (p=0.315). A family history of Kawasaki disease was not associated with significantly different rates of IVIG resistance compared to no family history (8.3% vs. 22.1%, P=0.315).
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