Key result
Acute phase treatment for Kawasaki disease resulted in coronary artery lesion rates of 1.9% at 1 month and 0.9% at 1 year, with no patients developing coronary artery stenosis.
Why the study?
An acute phase treatment for the prevention of coronary artery stenosis caused by Kawasaki disease has not been established.
Cohort (n=214)
No
Acute phase treatment for Kawasaki disease, primarily with single-dose IVIG, is associated with very low rates of coronary artery lesions and no medium-term cardiac events requiring therapy.
Medium-term KD outcomes after mostly standard IVIG warrant continued surveillance; leaves open optimal regimens to prevent stenosis.
An acute phase treatment for prevention of coronary artery stenosis caused by Kawasaki disease (KD) has not been established. The objective of this study was to clarify the medium-term outcomes of patients who received acute phase treatment in our department. This retrospective study included data from 214 patients with KD who received acute phase treatment from January 2009 to May 2020. A total of 196 (92.1%) received an initial single dose of intravenous immunoglobulin (IVIG) therapy. One patient with status epilepticus at presentation received initial IVIG plus steroid therapy. A total of 17 patients did not receive IVIG. The rate of coronary artery lesions (CALs) 1 month and 1 year after KD onset were 1.9% and 0.9%, respectively. Two patients had CAL 1 year after KD onset. However, no patients had coronary artery stenosis. One patient with a right giant CAL had a medium CAL before initial therapy. During a median follow-up period of 3 years and 4 months, no patients had cardiac events that required therapy.
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Toshimasa Nakada (2020) conducted a cohort in Kawasaki disease (n=214). Acute phase treatment was evaluated on Coronary artery lesions at 1 month. Acute phase treatment for Kawasaki disease resulted in coronary artery lesion rates of 1.9% at 1 month and 0.9% at 1 year, with no patients developing coronary artery stenosis.
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