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There are two inhibitors of plasmin in the plasma proteins of the human. alpha1-antiplasmin is heat-labile and migrates as an alpha1-globulin on electrophoresis. It combines non-dissociably with plasmin at a rate that depends on temperature. alpha2-antiplasmin is relatively more heat-stable and migrates as an alpha2-globulin on electrophoresis. It combines dissociably with plasmin independently of temperature.
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Norman et al. (1958) studied this question.
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