Why the study?
Does human plasmin inhibit platelet function and arachidonic acid metabolism in human platelets?
Population
Human platelets washed by gel filtration
Comparison
Human plasmin (0.1-1.0 caseinolytic units [CU]/ml) vs Untreated platelets
Design
Preclinical
Authors
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May contribute to bleeding during fibrinolysis; leaves open translation from animal platelets to humans.
Does human plasmin inhibit platelet function and arachidonic acid metabolism in human platelets?
Plasmin inhibits platelet function by blocking the mobilization of arachidonic acid from membrane phospholipids, providing a mechanism for hemostatic abnormalities during fibrinolysis.
Schafer et al. (1985) studied this question.
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