Key result
Preoperative platelet receptor dysfunction was not correlated with mild to moderate liver and kidney injury, but was significantly associated with a decreased platelet count.
Why the study?
Platelet dysfunction causes postoperative bleeding with incompletely understood etiology, and reliable assessment of platelet receptor activity may balance thrombotic and bleeding risks in cardiac surgery.
Does platelet receptor dysfunction correlate with organ dysfunction or transfusion requirements in patients qualified for cardiac surgery?
Population
71 cardiac surgical patients
Comparison
Platelet dysfunction groups by ADP and ASPI tests vs no dysfunction
Design
Observational study
Authors
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May aid perioperative bleeding risk stratification via point-of-care platelet testing in antiplatelet patients; hypothesis-generating, should not yet change practice.
Observational (n=71)
No
Does platelet receptor dysfunction correlate with organ dysfunction or transfusion requirements in patients qualified for cardiac surgery?
Effect estimate: rs = 0.55
p-value: p=<0.001
In patients undergoing cardiac surgery, platelet receptor dysfunction is common and correlates with platelet count, but does not appear to be driven by mild-to-moderate liver or kidney injury, nor does it predict postoperative transfusion needs.
Kosiorowska et al. (2018) conducted an observational in Cardiac surgery (n=71). Platelet receptor dysfunction vs. Normal platelet receptor activity was evaluated on Correlation between ADP receptor activity and platelet count (rs = 0.55, p=<0.001). Preoperative platelet receptor dysfunction was not correlated with mild to moderate liver and kidney injury, but was significantly associated with a decreased platelet count.
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