Key result
Induction of experimental renal hypertension in chronic spinal dogs caused a marked rise in peripheral resistance without changing stroke volume, heart rate, or cardiac output.
In chronic spinal dogs with complete cardiovascular denervation, experimental renal hypertension is driven by humoral factors increasing peripheral resistance rather than cardiac output.
No takes yet. Share an insight, caveat, or question.
Should not change hypertension management; leaves open humoral mediation of resistance in denervated states pending human data.
Kaneko et al. (1964) studied Normotensive and renal hypertensive chronic spinal dogs. High spinal cord section and experimental renal hypertension vs. Pre-operative control levels was evaluated on Hemodynamic changes (stroke volume, cardiac output, aortic pressure, heart rate, peripheral resistance). Induction of experimental renal hypertension in chronic spinal dogs caused a marked rise in peripheral resistance without changing stroke volume, heart rate, or cardiac output.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: