Key result
Various classes of antihypertensive drugs impact age-associated parameters of vascular aging, including endothelial dysfunction, pulse wave velocity, and intima-media thickness.
Why the study?
Do various classes of antihypertensive drugs improve parameters of vascular aging in patients with hypertension?
Do various classes of antihypertensive drugs improve parameters of vascular aging in patients with hypertension?
This review highlights the impact of different antihypertensive medications on surrogate markers of vascular aging, such as arterial stiffness and endothelial dysfunction.
Should not yet alter drug selection; leaves open whether vascular effects improve outcomes in older adults.
The review summarizes the data of past two decades on the effect of hypertension on vascular aging and considers the effect of chronic inflammation and oxidative stress patterns on the remodeling of cardiovascular system. Clinical studies on the effect of various classes of antihypertensive drugs on age-associated parameters of vascular aging are discussed. These include endothelial dysfunction and arterial assessed by endothelium-dependent vasodilation, pulse wave velocity, augmentation index, cardiovascular index, thickness of the intima-media complex, and so on.
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Dudinskaya et al. (2021) conducted a review in Hypertension and vascular aging. Antihypertensive medications was evaluated on Age-associated parameters of vascular aging (e.g., endothelial dysfunction, pulse wave velocity). Various classes of antihypertensive drugs impact age-associated parameters of vascular aging, including endothelial dysfunction, pulse wave velocity, and intima-media thickness.
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