Key result
The ACS digoxin assay demonstrated improved specificity and correlated well with TDx (r=0.961), Stratus (r=0.973), and Magic (r=0.982) assays, while avoiding interference from digoxin-like factors.
Why the study?
Does the Ciba Corning ACS digoxin assay provide improved specificity compared to other digoxin assays in patient sera?
Population
121 sera from 49 patients
Comparison
Ciba Corning ACS digoxin assay vs Abbott TDx, Baxter Stratus, and Ciba Corning…
Design
Other
Authors
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May improve digoxin monitoring specificity in renal or hepatic disease; leaves open prospective validation before clinical adoption.
Does the Ciba Corning ACS digoxin assay provide improved specificity compared to other digoxin assays in patient sera?
The Ciba Corning ACS digoxin assay offers improved specificity over other common assays, particularly by avoiding cross-reactivity with digoxin-like immunoreactive factor in patients with renal or hepatic disease.
Miller et al. (1996) studied Patients requiring digoxin level monitoring (n=49). Ciba Corning ACS digoxin assay vs. Abbott TDx, Baxter Stratus, and Ciba Corning Magic RIA digoxin assays was evaluated on Assay correlation and cross-reactivity. The ACS digoxin assay demonstrated improved specificity and correlated well with TDx (r=0.961), Stratus (r=0.973), and Magic (r=0.982) assays, while avoiding interference from digoxin-like factors.
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