Key result
Pre-operative qSOFA scores ≥2 were associated with a 3.54-fold higher odds of 30-day mortality after major surgery compared to a score of 0 (P<0.001).
Why the study?
Although intended for sepsis prognosis, qSOFA may help predict mortality in nonseptic patients, motivating an investigation of its relationship with 30-day mortality after major surgery alone and combined with ASA physical status and CCI.
Does a higher pre-operative qSOFA score predict increased 30-day mortality in patients undergoing major surgery?
Observational (n=6,336)
No
Does a higher pre-operative qSOFA score predict increased 30-day mortality in patients undergoing major surgery?
Odds Ratio: 3.54
p-value: p=<0.001
Higher pre-operative qSOFA scores within 24 hours of major surgery are associated with increased 30-day mortality and improve predictive value when combined with ASA physical status or CCI.
Preoperative qSOFA may aid mortality risk stratification after major surgery; leaves open added value beyond ASA and CCI.
BACKGROUND: The quick Sequential Organ Failure Assessment (qSOFA) is intended for the assessment of the prognosis and risk of sepsis. It may also help predict the mortality risk of nonseptic patients. OBJECTIVE: This study investigated the relationship between pre-operative qSOFA scores and 30-day mortality after major surgery. It also evaluated the predictive value of qSOFA scores combined with the American Society of Anesthesiologists (ASA) physical status and Charlson comorbidity index (CCI). DESIGN: A retrospective observational study. SETTING: Single tertiary academic hospital. PATIENTS: Medical records of patients who underwent major surgery (estimated blood loss >500 ml; surgery time >2 h) between January 2010 and December 2017 were examined. MAIN OUTCOME MEASURES: The qSOFA score was measured within 24 h before surgery, and its association with 30-day mortality was analysed using multivariable logistic regression. A receiver-operating characteristic curve analysis was used to investigate the predictive power of the pre-operative qSOFA scores combined with the ASA physical status and with CCI. RESULTS: A total of 6336 patients were included in the final analysis, and 91 (1.4%) died within 30 days. The multivariable logistic regression analysis including all covariates indicated that 30-day mortality was 2.43-times higher for the score 1 group than for the score 0 group (P = 0.002), and it was 3.54-times higher for the score at least 2 group than for the score 0 group (P < 0.001). The area under the curve (AUC) of the pre-operative qSOFA, ASA physical status and CCI were 0.69, 0.55 and 0.57, respectively. When the pre-operative qSOFA score was combined with the ASA physical status or CCI, the AUCs were 0.73 and 0.72, respectively. CONCLUSION: Higher pre-operative qSOFA scores within 24 h of surgery were associated with increased 30-day mortality. Pre-operative qSOFA scores have better predictive value for 30-day mortality when combined with the ASA physical status or CCI.
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Oh et al. (2019) conducted an observational in major surgery (n=6,336). Pre-operative qSOFA score ≥2 vs. qSOFA score 0 was evaluated on 30-day mortality (OR 3.54, p=<0.001). Pre-operative qSOFA scores ≥2 were associated with a 3.54-fold higher odds of 30-day mortality after major surgery compared to a score of 0 (P<0.001).
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