Key result
A natriuretic substance from human plasma and urine (molecular weight 10,000-50,000) induced delayed, prolonged natriuresis in rats without altering GFR or blood pressure.
Identifies and characterizes a natriuretic substance from human plasma and urine that acts on the distal tubule to depress sodium reabsorption.
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No immediate clinical implications; leaves open the factor's physiologic role and therapeutic potential in humans.
Sealey et al. (1971) studied this question. Natriuretic agent extracted from human plasma and urine was evaluated on Natriuresis. A natriuretic substance from human plasma and urine (molecular weight 10,000-50,000) induced delayed, prolonged natriuresis in rats without altering GFR or blood pressure.
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