Key result
Protein removal by ultrafiltration eliminated false-positive digoxin measurements in 100% of 53 patients with endogenous digoxin-like immunoreactivity compared to precipitation with 5-sulfosalicylic acid.
Why the study?
Does centrifugal ultrafiltration eliminate digoxin-like immunoreactivity interference compared to SSA precipitation in fluorescence polarization immunoassay of digoxin?
Population
75 serum samples, including 53 from patients not receiving digoxin and 22 from men prescribed digoxin.
Comparison
Centrifugal ultrafiltration for protein removal… vs Precipitation of protein with 5-sulfosalicylic…
Design
Other
Authors
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May enhance digoxin assay accuracy; leaves open whether ultrafiltration should replace SSA precipitation.
Does centrifugal ultrafiltration eliminate digoxin-like immunoreactivity interference compared to SSA precipitation in fluorescence polarization immunoassay of digoxin?
Centrifugal ultrafiltration effectively eliminates endogenous digoxin-like immunoreactivity interference in fluorescence polarization immunoassays, improving diagnostic accuracy for digoxin levels.
Christenson et al. (1987) studied Digoxin-like immunoreactivity interference (n=75). Ultrafiltration vs. Precipitation with 5-sulfosalicylic acid (SSA) was evaluated on Measurable digoxin immunoreactivity in patients not receiving digoxin. Protein removal by ultrafiltration eliminated false-positive digoxin measurements in 100% of 53 patients with endogenous digoxin-like immunoreactivity compared to precipitation with 5-sulfosalicylic acid.
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