Key result
Chronic alcohol abuse in patients with septic shock was associated with an increased incidence of acute respiratory distress syndrome (70% vs 31%; adjusted OR 3.70; 95% CI 1.83-7.71; p<0.001).
Why the study?
Does chronic alcohol abuse increase the incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock?
Cohort (n=220)
Yes
Does chronic alcohol abuse increase the incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock?
Odds Ratio: 3.7 (95% CI 1.83–7.71)
Absolute Event Rate: 70% vs 31%
p-value: p=<0.001
Chronic alcohol abuse is an independent risk factor for developing ARDS and more severe nonpulmonary organ dysfunction in patients with septic shock.
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Chronic alcohol abuse may flag higher ARDS risk in septic shock; hypothesis-generating for targeted prevention trials.
Moss et al. (2003) conducted a cohort in Septic shock (n=220). Chronic alcohol abuse vs. No history of chronic alcohol abuse was evaluated on Incidence of acute respiratory distress syndrome (OR 3.70, 95% CI 1.83-7.71, p=<0.001). Chronic alcohol abuse in patients with septic shock was associated with an increased incidence of acute respiratory distress syndrome (70% vs 31%; adjusted OR 3.70; 95% CI 1.83-7.71; p<0.001).
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