Key result
Small-for-gestational age fetuses had significantly lower pulmonary and higher aortic time to peak velocity than AGA fetuses, with aortic values normalizing during maternal hyperoxygenation.
Why the study?
Does maternal hyperoxygenation affect the time to peak velocity in the aorta and pulmonary artery of small for gestational age fetuses?
Observational (n=180)
Does maternal hyperoxygenation affect the time to peak velocity in the aorta and pulmonary artery of small for gestational age fetuses?
Maternal hyperoxygenation partially normalizes altered aortic time to peak velocity in small-for-gestational age fetuses, suggesting reversible changes in peripheral resistance.
May indicate reversible aortic flow changes in SGA fetuses; hypothesis-generating, should not yet change practice.
The time to peak velocity was measured at the level of the ascending aorta and pulmonary artery by Doppler echocardiography in 38 small-for-gestational age (SGA) fetuses before and during maternal hyperoxygenation. The values were compared to a reference range derived from the study of 142 appropriate-for-gestational age (AGA) fetuses. In the SGA fetuses the time to peak velocity at the level of pulmonary artery was significantly lower and at the level of the aorta significantly higher than in AGA fetuses. During maternal hyperoxygenation the aortic time to peak velocity decreased towards normal range but there was no significant change at the level of the pulmonary artery. These results may indicate variations of aortic and pulmonary pressures in SGA fetuses that can be partially modified by maternal hyperoxygenation and which may be associated with changes in the peripheral resistance of the cerebral circulation.
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Rizzo et al. (1990) conducted an observational in Small for gestational age (SGA) fetuses (n=180). Small for gestational age (SGA) and maternal hyperoxygenation vs. Appropriate for gestational age (AGA) fetuses and baseline was evaluated on Time to peak velocity at the level of the ascending aorta and pulmonary artery. Small-for-gestational age fetuses had significantly lower pulmonary and higher aortic time to peak velocity than AGA fetuses, with aortic values normalizing during maternal hyperoxygenation.
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