Key result
Amlodipine or lisinopril was not better than chlorthalidone in lowering CHD risk in high-risk hypertensive patients.
RCT
Source Citation The ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002;288:2981-97. 12479763 (All 2003 articles were reviewed for relevancy, and abstracts were last revised in 2009.)
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Bruce M. Psaty (2003) conducted an RCT in Hypertension. Amlodipine or lisinopril vs. Chlorthalidone was evaluated on CHD risk. Amlodipine or lisinopril was not better than chlorthalidone in lowering CHD risk in high-risk hypertensive patients.
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