Why the study?
Do chlorthalidone, lisinopril, or amlodipine differ in preventing coronary heart disease in high-risk individuals with mild-to-moderate hypertension?
Population
42,418 high-risk individuals with mild-to-moderate hypertension, including 36% with diabetes
Comparison
Chlorthalidone, lisinopril, or amlodipine vs Active comparators
Design
Review, randomised
Authors
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Should not alter hypertension prescribing; leaves open optimal first-line agent selection in high-risk patients.
Do chlorthalidone, lisinopril, or amlodipine differ in preventing coronary heart disease in high-risk individuals with mild-to-moderate hypertension?
Despite its large size, the ALLHAT trial's design and conduct limit its practical implications for the management of hypertension.
Gordon T. McInnes (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: