Key result
High-intensity interval training improved exercise capacity (MD 3.5; 95% CI 2.3-4.7; P<0.00001) and peak heart rate compared to no exercise training in heart transplant recipients.
Why the study?
Heart transplantation is the gold standard for selected individuals with refractory heart failure, and HIIT is safe and allows exercise at high intensity longer than MICT, but its comparative effects in these recipients warranted synthesis.
Does high-intensity interval training improve exercise capacity, peak heart rate, and heart rate reserve in heart transplant recipients compared to moderate-intensity continuous training?
Meta-Analysis
Does high-intensity interval training improve exercise capacity, peak heart rate, and heart rate reserve in heart transplant recipients compared to moderate-intensity continuous training?
High-intensity interval training improves peak heart rate and potentially exercise capacity in heart transplant recipients, though further studies using isocaloric protocols are needed to confirm superiority over moderate-intensity continuous training.
HIIT may be preferred over MICT for exercise capacity gains in HTx recipients; extends limited RCT evidence but warrants isocaloric trials.
INTRODUCTION: Heart transplantation (HTx) is the gold standard procedure for selected individuals with refractory heart failure. Highintensity interval training (HIIT) is safe and allows patients to exercise in high intensity for longer time when compared to moderateintensity continuous training (MICT). The primary aim of this study was to perform a systematic review and meta-analysis about the effect of HIIT compared to MICT on exercise capacity, peak heart rate, and heart rate reserve in HTx recipients. Secondarily, we pooled data comparing MICT and no exercise training in these patients. METHODS: This systematic review followed the standardization of the Preferred Reporting Items for Systematic Reviews and Metaanalyses statement and the Cochrane Collaboration Handbook. We presented the treatment effects of HIIT on the outcomes of interest as mean difference (MD) and 95% confidence interval (CI). Metaanalysis was performed using the random-effects, generic inverse variance method. RESULTS: (MD = 3.5; 95% CI 2.3, 4.7; P<0.00001) and peak heart rate (MD = 5.6; 95% CI 1.6, 9.6; P=0.006) were found comparing HIIT and no exercise training. However, the superiority of HIIT should be tested in isocaloric protocols.
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Conceição et al. (2020) conducted a meta-analysis in Heart Transplant. High-intensity interval training (HIIT) vs. Moderate-intensity continuous training (MICT) or no exercise training was evaluated on Exercise capacity (MD 3.5, 95% CI 2.3, 4.7, p=<0.00001). High-intensity interval training improved exercise capacity (MD 3.5; 95% CI 2.3-4.7; P<0.00001) and peak heart rate compared to no exercise training in heart transplant recipients.
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