Key result
Metabolic syndrome defined by NCEP ATP III criteria significantly predicted incident cardiovascular disease in rural elderly females (HR 1.45), but not in males.
Why the study?
The predictive effect of metabolic syndrome and its components on cardiovascular disease according to different metabolic syndrome criteria remained to be evaluated in rural Chinese elderly.
Does metabolic syndrome predict newly onset cardiovascular disease in rural Chinese elderly?
Cohort (n=2,486)
Does metabolic syndrome predict newly onset cardiovascular disease in rural Chinese elderly?
Hazard Ratio: 1.45 (95% CI 1–2.1)
Metabolic syndrome is a significant predictor of incident cardiovascular disease in elderly rural Chinese women, but not men, particularly when using NCEP ATP III criteria.
May inform sex-specific CVD risk assessment in rural elderly; hypothesis-generating and should not yet change practice.
Background To evaluate the possible predictive effect of metabolic syndrome (MetS) and its components on cardiovascular disease (CVD) in a longitudinal analysis according to different criteria of MetS among rural Chinese elderly. Method A population-based sample of 2486 rural elderly Chinese residents aged ≥ 60 years at baseline were followed up from 2012–2013 to 2015–2017. CVD included stroke, coronary heart disease (CHD) diagnosed by clinicians were self-reported and were confirmed by medical records. MetS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) and the international Diabetes Federation (IDF) criterion respectively. Result Hazard ratio adjusting for CHD, Stroke and CVD in those with MetS using NCEP ATP III criteria in female were 1.27 (95%CI 0.73, 2.21), 1.54 (95%CI 0.99, 2.40) and 1.45 (95%CI 1.00, 2.10); 1.33 (95%CI 0.77, 2.32), 1.44 (95%CI 0.92, 2.25) and 1.36 (95%CI 0.94, 1.97) with the AHA/NHLBI criteria; and 1.10 (95%CI 0.89,1.36), 1.62 (95%CI 1.03, 2.55) and 1.36 (95%CI 0.93, 1.97) with IDF criteria. Besides, abdominal obesity using the AHA/NHLBI criteria was significantly associated with the incidence of stroke (HR: 1.60; 95%CI 1.01, 2.52). However, among rural male elderly, neither MetS nor its components were capable of predicting newly onset CVD. Conclusion MetS is significantly associated with high incidence of CVD among rural female elderly only, and the incidence of CVD was evident only when MetS was defined using NCEP ATP III criterion. In order to reduce CVD among elderly in rural China, effective strategies to prevent, diagnose, and treating MetS should be made in time, especially among female.
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Yu et al. (2020) conducted a cohort in Cardiovascular disease (n=2,486). Metabolic syndrome (NCEP ATP III criteria) vs. Without metabolic syndrome was evaluated on Incident cardiovascular disease (composite of new onset stroke or CHD) in females (HR 1.45, 95% CI 1.00, 2.10). Metabolic syndrome defined by NCEP ATP III criteria significantly predicted incident cardiovascular disease in rural elderly females (HR 1.45), but not in males.
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