Etiology of Bacterial Endocarditis

Article1 June 1963Etiology of Bacterial EndocarditisBefore and Since the Introduction of AntibioticsLARKIN M. WILSON, M.D.LARKIN M. WILSON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-6-946 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the introduction of antimicrobial agents into clinical medicine, many significant changes have been noted in certain aspects of infectious diseases. These drugs have favorably affected the occurrence, natural history, clinical course, and the mortality, as well as the morbidity, of some of the specific bacterial infections. Also, definite changes have been impressively demonstrated by Finland and others concerning the alteration in the causative bacterial flora of such infections as meningitis, empyema, septicemia, and terminal pneumonia (1, 2). Though it is generally assumed that the causative organisms of endocarditis are also changing, this impression can only be supported by the...References1. FINLANDJONESBARNES MWFMW: Occurrence of serious bacterial infections since introduction of antibacterial agents. JAMA 170: 2188, 1959. CrossrefMedlineGoogle Scholar2. KNEELANDPRICE YKM: Antibiotics and terminal pneumonia. Amer. J. Med. 29: 967, 1960. CrossrefMedlineGoogle Scholar3. THAYER WS: Bacteria of infectious endocarditis. Edinburgh Med. J. 38: 237, 1931. MedlineGoogle Scholar4. MEADS WS: Bacteria of infectious endocarditis with penicillin. New Eng. J. Med. 232: 463, 1945. CrossrefGoogle Scholar5. GLASSERSMITHHARTFORDWOOD RJROCGWB: The treatment of bacterial endocarditis with penicillin. J. Lab. Clin. Med. 31: 291, 1946. MedlineGoogle Scholar6. LEVINSONGRIFFITHPEARSON DCGCHE: Increasing bacterial resistance to the antibiotics. Circulation 2: 668, 1950. CrossrefMedlineGoogle Scholar7. 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Heart J. 59: 184, 1960. CrossrefMedlineGoogle Scholar14. SHUBINLEVINSONGRIFFITH HDCGC: Endocarditis due to coagulase positive staphylococcus pyogenes var. aureus. JAMA 167: 1218, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: El Dorado, ArkansasFrom the Department of Medicine, University Hospitals, Cleveland, Ohio.Requests for reprints should be addressed to Larkin M. Wilson, M.D., 430 South West Avenue, El Dorado, Arkansas. 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