Key result
Isoflurane-induced hypotension significantly reduced blood loss compared to control (454.0 vs 755.3 mL, P<0.001) and decreased the need for transfusions (12.0% vs 44.4%, P<0.02).
Why the study?
Does isoflurane-induced hypotension reduce blood loss in patients undergoing combined maxillary and mandibular osteotomies?
Does isoflurane-induced hypotension reduce blood loss in patients undergoing combined maxillary and mandibular osteotomies?
Absolute Event Rate: 454% vs 755.3%
p-value: p=<0.001
Isoflurane-induced hypotension effectively reduces blood loss and the need for transfusions during orthognathic surgery without affecting operative time or postoperative edema.
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Isoflurane-induced hypotension was associated with reduced blood loss and transfusions in orthognathic surgery; hypothesis-generating and requires randomized confirmation before practice change.
Lessard et al. (1989) studied Orthognathic surgery (n=52). Isoflurane-induced hypotension vs. Control group (MAP 75-85 mm Hg) was evaluated on Blood loss (p=<0.001). Isoflurane-induced hypotension significantly reduced blood loss compared to control (454.0 vs 755.3 mL, P<0.001) and decreased the need for transfusions (12.0% vs 44.4%, P<0.02).
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