Key result
Transfemoral TAVI resulted in transient depression of left ventricular function and significant increases in troponin I (0.07 to 1.59 μg/l; p<0.005) and CK-MB within 24 hours postprocedure.
Why the study?
Does transfemoral TAVI cause early haemodynamic changes and myocardial injury in patients with severe aortic stenosis?
Population
42 consecutive patients with severe aortic stenosis referred for transfemoral transcatheter aortic valve…
Design
Cohort, Echocardiography images were stored digitally and subsequently…
Follow-up
24 hours (with 30-day mortality reported retrospectively)
Authors
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Transient LV dysfunction and injury markers after TAVI warrant early monitoring; leaves open prognostic impact on outcomes.
Observational (n=42)
No
Does transfemoral TAVI cause early haemodynamic changes and myocardial injury in patients with severe aortic stenosis?
p-value: p=<0.005
Successful transfemoral TAVI is associated with transient left ventricular systolic and diastolic dysfunction and myocardial injury within the first 24 hours, which generally recovers completely by 24 hours.
Dworakowski et al. (2012) conducted an observational in Patients undergoing transfemoral TAVI (n=42). Transfemoral transcatheter aortic valve implantation (TAVI) vs. Baseline (pre-procedure) was evaluated on Haemodynamic changes, myocardial function indices, and myocardial injury (troponin I and CK-MB) at 6 and 24 hours postprocedure (p=<0.005). Transfemoral TAVI resulted in transient depression of left ventricular function and significant increases in troponin I (0.07 to 1.59 μg/l; p<0.005) and CK-MB within 24 hours postprocedure.
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