Key result
A lower aldosterone/renin ratio, higher soluble ACE2 levels, and the TMPRSS2 rs2070788 non-AA genotype were independently associated with severe COVID-19, yielding a combined predictive C-index of 0.79.
Why the study?
COVID-19 severity after SARS-CoV-2 infection is unpredictable, prompting an investigation into parameters determining severity with a focus on RAAS components and ACE2 and TMPRSS2 genetic variation.
Observational (n=188)
No
Odds Ratio: 0.73 (95% CI 0.59–0.89)
p-value: p=0.0037
High soluble ACE2, a low aldosterone/renin ratio, and the TMPRSS2 rs2070788 non-AA genotype are independent predictors of COVID-19 severity in hospitalized patients, independent of RAAS blocker use.
May heighten SARS-CoV-2 susceptibility in hypertension; leaves open clinical relevance of RAAS effects pending validation.
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A 2021 study conducted an observational in COVID-19 (n=188). Aldosterone/renin ratio vs. Higher aldosterone/renin ratio was evaluated on Severe COVID-19 (ICU admission and/or all-cause death) (OR 0.73, 95% CI 0.59-0.89, p=0.0037). A lower aldosterone/renin ratio, higher soluble ACE2 levels, and the TMPRSS2 rs2070788 non-AA genotype were independently associated with severe COVID-19, yielding a combined predictive C-index of 0.79.
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