Key result
The aldosterone/renin ratio demonstrated a high sensitivity of 91.2% as a screening test for primary aldosteronism when evaluated in patients with low plasma renin activity.
Why the study?
Does the aldosterone/renin ratio accurately screen for primary aldosteronism in hypertensive patients?
Observational (n=309)
No
Does the aldosterone/renin ratio accurately screen for primary aldosteronism in hypertensive patients?
The aldosterone/renin ratio demonstrates high sensitivity (91%) for screening primary aldosteronism in hypertensive patients when used appropriately.
INTRODUCTION: The diagnostic algorithm of primary aldosteronism is burdened with uncertainties and, recently, it has been suggested that the sensitivity of the aldosterone/renin ratio used as a screening test - based on the suppression aldosterone - is low. AIM: The primary aim was to test the accuracy of aldosterone/renin ratio. METHOD: In a retrospective analysis of 309 hypertensive patients supine and ambulatory aldosterone levels were independently examined. RESULTS: Aldosterone/renin ratio was elevated in 99 patients of whom 31 exhibited elevated supine aldosterone, as well. In 34 cases supine aldosterone was increased without elevation of the aldosterone/renin ratio. However, only 3 of them had concomitant low renin levels indicating that primary aldosteronism could not be ruled out. Abnormally increased renin was found in 69 patients, but only 59% of them had increased aldosterone level. CONCLUSION: Sensitivity of aldosterone/renin ratio is high (91%) if used only in justified cases.
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Hussein et al. (2016) conducted an observational in Hypertension (n=309). Aldosterone/renin ratio (ARR) vs. Supine suppression aldosterone and plasma renin activity was evaluated on Sensitivity of the aldosterone/renin ratio for detecting primary aldosteronism. The aldosterone/renin ratio demonstrated a high sensitivity of 91.2% as a screening test for primary aldosteronism when evaluated in patients with low plasma renin activity.
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