Screening for Primary Aldosteronism: Implications of an Increased Plasma Aldosterone/Renin Ratio
Why the study?
Does the plasma aldosterone/renin ratio accurately identify patients at risk for primary aldosteronism among adults with essential hypertension?
Population
505 adults with essential hypertension (143 black women, 82 black men, 122 white women, and 158 white men)
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
ARR should not yet guide primary aldosteronism screening in essential hypertension; leaves open need for validated thresholds or alternative markers.
Structured PICO
Does the plasma aldosterone/renin ratio accurately identify patients at risk for primary aldosteronism among adults with essential hypertension?
P
Population
505 adults with essential hypertension (143 black women, 82 black men, 122 white women, and 158 white men)
I
Intervention
Plasma aldosterone/renin ratio (using a cutpoint of 20 mL/dL x h)
O
Outcome
Sensitivity, specificity, and predictive value of the aldosterone/renin ratio to identify combinations of renin and aldosterone compatible with primary aldosteronismsurrogate
The plasma aldosterone/renin ratio lacks sufficient sensitivity and specificity, and has only modest predictive value for identifying primary aldosteronism in adults with essential hypertension.
Cite This Study
Schwartz et al. (2002) studied this question.