Key result
Activation of the HIF-1a-PPAR axis by pathologic stress is proposed to underlie the metabolic shift from fatty acid oxidation to glycolysis during cardiac hypertrophy and progression to heart failure.
Population
Models of cardiac hypertrophy and progression to heart failure
Design
Editorial
Authors
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Highlights the maladaptive role of chronic HIF-1 pathway activation and the HIF-1a-PPAR axis in the metabolic shift during cardiac hypertrophy.
Highlights the maladaptive role of chronic HIF-1 pathway activation and the HIF-1a-PPAR axis in the metabolic shift during cardiac hypertrophy.
Kaur et al. (2009) conducted a review in Cardiac hypertrophy and heart failure. Activation of the HIF-1a-PPAR axis was evaluated on Changes in cell metabolism contributing to cardiac hypertrophy and transition to heart failure. Activation of the HIF-1a-PPAR axis by pathologic stress is proposed to underlie the metabolic shift from fatty acid oxidation to glycolysis during cardiac hypertrophy and progression to heart failure.
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