Key result
Weight loss via surgery or diet decreased total myocardial oxygen consumption, which independently predicted improved left ventricular relaxation (P=0.02).
Why the study?
Does weight loss improve myocardial metabolism and left ventricular diastolic function in obese humans?
Population
30 obese (BMI >30 kg/m2) subjects
Comparison
Weight loss via gastric bypass surgery or diet vs Baseline (before weight loss)
Design
Cohort
Authors
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Weight loss may aid diastolic function in obesity; extends metabolic observations but leaves causality and clinical adoption open.
Cohort (n=30)
Does weight loss improve myocardial metabolism and left ventricular diastolic function in obese humans?
p-value: p=0.02
Weight loss improves obesity-related derangements in myocardial metabolism and diastolic function, with decreased myocardial oxygen consumption independently predicting improved left ventricular relaxation.
Lin et al. (2011) conducted a cohort in Obesity (n=30). Weight loss (gastric bypass surgery or diet) vs. Baseline (before weight loss) was evaluated on Total myocardial oxygen consumption (MVO2) and left ventricular relaxation (p=0.02). Weight loss via surgery or diet decreased total myocardial oxygen consumption, which independently predicted improved left ventricular relaxation (P=0.02).
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