Key result
Propofol provided greater autonomic protection regardless of initial autonomic status, while sodium thiopental provided more stable hemodynamic parameters in children undergoing ENT surgery.
Why the study?
Autonomic homeostasis during general anesthesia depends on both anesthetic properties and baseline autonomic status, but the impact of different anesthetics on heart rate variability across autonomic profiles in pediatric surgery was unclear.
Does the choice of anesthetic drug (ketamine, thiopental, propofol) affect heart rate variability and hemodynamics differently based on initial vegetative status in children undergoing otorhinolaryngological surgery?
Observational (n=105)
Does the choice of anesthetic drug (ketamine, thiopental, propofol) affect heart rate variability and hemodynamics differently based on initial vegetative status in children undergoing otorhinolaryngological surgery?
Propofol may offer better autonomic protection during pediatric ENT surgery, especially in children with baseline sympathicotonia who are more vulnerable to hemodynamic and HRV fluctuations.
May guide induction agent selection balancing autonomic-hemodynamic trade-offs in children; leaves open optimal choice pending RCTs.
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Аleksаndrovich et al. (2021) conducted an observational in Otorhinolaryngological surgery under general anesthesia (n=105). Propofol, Thiopental, or Ketamine vs. Compared to each other was evaluated on Heart rate variability and hemodynamic parameters. Propofol provided greater autonomic protection regardless of initial autonomic status, while sodium thiopental provided more stable hemodynamic parameters in children undergoing ENT surgery.
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