Key result
Sympathetic nerve stimulation of isolated blood vessels produces a linear frequency response curve within the physiological range, influenced by innervation density and alpha-adrenergic sensitivity.
Population
Isolated blood vessels
Design
Preclinical
Authors
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No immediate clinical implications for vascular tone; leaves open translation of myogenic mechanisms to human sympathetic control.
The study proposes that a local limited myogenic extension of excitation may extend the local action of a quantum of transmitter during sympathetic nerve stimulation of blood vessels.
John A. Bevan (2008) studied this question. Sympathetic nerve stimulation was evaluated on Frequency response curves (FRC). Sympathetic nerve stimulation of isolated blood vessels produces a linear frequency response curve within the physiological range, influenced by innervation density and alpha-adrenergic sensitivity.
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