Key result
Antiarrhythmic drugs that block the sodium channel can increase the duration of the cardiac vulnerable period by slowing conduction velocity and reducing the gradient of excitability.
Why the study?
How do sodium channel-blocking antiarrhythmic drugs increase the rate of sudden cardiac death in a cardiac cell model?
How do sodium channel-blocking antiarrhythmic drugs increase the rate of sudden cardiac death in a cardiac cell model?
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Computational modeling suggests that sodium channel-blocking antiarrhythmic drugs increase sudden cardiac death risk by prolonging the vulnerable period via slowed conduction and reduced excitability gradients.
C F Starmer (2002) studied Sudden cardiac death and re-entrant tachyarrhythmias. Antiarrhythmic drugs that block the sodium channel was evaluated on Duration of the cardiac vulnerable period. Antiarrhythmic drugs that block the sodium channel can increase the duration of the cardiac vulnerable period by slowing conduction velocity and reducing the gradient of excitability.
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