Why the study?
Does intravenous hypertonic glucose solution treat Stokes-Adams syndrome caused by heart stoppage or ventricular fibrillation?
Does intravenous hypertonic glucose solution treat Stokes-Adams syndrome caused by heart stoppage or ventricular fibrillation?
This historical 1939 paper discusses the use of intravenous hypertonic glucose for the treatment of Stokes-Adams syndrome.
Does not support hypertonic glucose for Stokes-Adams attacks today; leaves open any modern role in bradyarrhythmic syncope.
Article1 July 1939TREATMENT OF THE STOKES-ADAMS SYNDROME BY HYPERTONIC GLUCOSE SOLUTION GIVEN INTRAVENOUSLYLOUIS H. SIGLER, M.D.LOUIS H. SIGLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-1-101 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough the symptom complex grouped under the heading of the Stokes-Adams syndrome may be caused by many conditions which produce temporary cerebral anemia, we will confine our discussion only to the two main conditions, namely stoppage of the heart and ventricular fibrillation. Furthermore, we shall eliminate from our discussion those cases of sino-auricular standstill or auriculo-ventricular block caused by direct or reflex vagal inhibition which can be abolished or successfully treated by atropine. This leaves us a group of cases where for some unknown reason there is a sudden interruption in the passage of the electrical impulse from the auricles...References1. DOCK W: Transitory ventricular fibrillation as a cause of syncope and its prevention by quinidine sulphate, Am. Heart Jr., 1928-29, iv, 709. Google Scholar2. SCHWARTZJEZER SPA: The action of adrenalin on patients with complete heart block and Stokes-Adams seizures, Am. Heart Jr., 1932, vii, 652. CrossrefGoogle Scholar3. PHEARPARKINSON J: Adrenalin in the Stokes-Adams syndrome, Lancet, 1922, i, 933. CrossrefGoogle Scholar4. LEVINEMATTON SAM: Observations on a case of Adams-Stokes syndrome showing ventricular fibrillation and asystole lasting five minutes with recovery following the intracardiac injection of adrenalin, Heart, 1925-26, xii, 271. Google Scholar5. CAHALL WL: Paroxysmal ventricular fibrillation, Jr. Am. Med. Assoc., 1935, cv, 2054. CrossrefGoogle Scholar6. LEVINE HD: Effect of quinidine sulphate in inhibiting ventricular fibrillation, Arch. Int. Med., 1932, xlix, 808. CrossrefGoogle Scholar7. ESCAMILLE RF: Report of case of paroxysmal ventricular fibrillation—quinidine therapy, Am. Heart Jr., 1932, viii, 850. Google Scholar8. KERRBENDER WJWL: Paroxysmal ventricular fibrillation with cardiac recovery in a case of auricular fibrillation and complete heart block while under quinidine sulphate therapy, Heart, 1922, ix, 269. Google Scholar9. SCHWARTZJEZER SPA: The action of quinidine in ventricular fibrillation, Am. Heart Jr., 1933-34, ix, 792. Google Scholar10. DAVISSPRAGUE DR: Ventricular fibrillation: its relation to heart block, Am. Heart Jr., 1929, iv, 559. CrossrefGoogle Scholar11. HERTEL E: Klinische Untersuchungen über die Abhängigkeit des Augendruckes von der Blutbeschaffenheit, Arch. f. Ophth., 1915, xc, 309. Google Scholar12. WEEDMCKIBBEN LHPS: Pressure changes in the cerebro-spinal fluid following intravenous injections of solutions of various concentrations, Am. Jr. Physiol., 1919, xlviii, 512. CrossrefGoogle Scholar13. SIGLER LH: Adams-Stokes syndrome induced by transient recurrent ventricular fibrillation, Am. Heart Jr., 1938, xvi, 109. CrossrefGoogle Scholar14. SIGLER LH: The fibrillatory phase of transient recurrent ventricular fibrillation, Internat. Clin., 1939, i, 221-226. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, N. Y.*Received for publication September 14, 1937. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAdams-Stokes syndromeTHE ELECTROCARDIOGRAM OF THE STOKES-ADAMS ATTACK 1 July 1939Volume 13, Issue 1Page: 101-106KeywordsAnemiaAtropineGlucoseHeartReflexesVentricular fibrillation ePublished: 1 December 2008 Issue Published: 1 July 1939 PDF downloadLoading ...
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Louis H. Sigler (1939) studied this question.
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