Key result
High serum cortisol level in the first postoperative morning was significantly associated with an increased risk of cognitive dysfunction seven days after coronary artery bypass graft surgery (OR 2.603).
Why the study?
Does high postoperative serum cortisol level predict cognitive dysfunction in adult patients early after elective CABG surgery?
Cohort (n=166)
Yes
Does high postoperative serum cortisol level predict cognitive dysfunction in adult patients early after elective CABG surgery?
Odds Ratio: 2.603 (95% CI 1.371–4.944)
p-value: p=0.003
High serum cortisol levels on the first postoperative morning are associated with an increased risk of early cognitive dysfunction following CABG surgery.
Postoperative cortisol may aid early risk stratification after CABG; hypothesis-generating for causal confirmation and preventive trials.
CONTEXT: Stress response induced by surgery is proposed to play an important role in the pathogenesis of postoperative cognitive dysfunction. OBJECTIVE: To investigate the association between postoperative serum cortisol level and occurrence of cognitive dysfunction early after coronary artery bypass graft surgery. DESIGN: Prospective cohort study. SETTING: Two teaching hospitals. PATIENTS: One hundred and sixth-six adult patients who were referred to elective coronary artery bypass graft surgery from March 2008 to December 2009. INTERVENTION: None. MAIN OUTCOME MEASURES: Neuropsychological tests were completed one day before and seven days after surgery. Cognitive dysfunction was defined using the same definition as used in the ISPOCD1-study. Blood samples were obtained in the first postoperative morning for measurement of serum cortisol concentration. Multivariate Logistic regression analyses were performed to assess the relationship between serum cortisol level and occurrence of postoperative cognitive dysfunction. RESULTS: Cognitive dysfunction occurred in 39.8% (66 of 166) of patients seven days after surgery. Multivariate Logistic regression analysis showed that high serum cortisol level was significantly associated with the occurrence of postoperative cognitive dysfunction (odds ratio [OR] 2.603, 95% confidence interval [CI] 1.371-4.944, P = 0.003). Other independent predictors of early postoperative cognitive dysfunction included high preoperative New York Heart Association functional class (OR 0.402, 95% CI 0.207-0.782, P = 0.007), poor preoperative Grooved Pegboard test score of nondominant hand (OR 1.022, 95% CI 1.003-1.040, P = 0.020), use of penehyclidine as premedication (OR 2.565, 95% CI 1.109-5.933, P = 0.028), and occurrence of complications within seven days after surgery (OR 2.677, 95% CI 1.201-5.963, P = 0.016). CONCLUSIONS: High serum cortisol level in the first postoperative morning was associated with increased risk of cognitive dysfunction seven days after coronary artery bypass graft surgery.
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Mu et al. (2013) conducted a cohort in Postoperative cognitive dysfunction (n=166). High postoperative serum cortisol level vs. Lower postoperative serum cortisol level was evaluated on Occurrence of postoperative cognitive dysfunction 7 days after surgery (OR 2.603, 95% CI 1.371-4.944, p=0.003). High serum cortisol level in the first postoperative morning was significantly associated with an increased risk of cognitive dysfunction seven days after coronary artery bypass graft surgery (OR 2.603).
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