Key result
Low pre-operative cognitive function (MoCA < 26) was associated with higher post-operative IL-6 concentrations (β = -0.212, p = 0.021) and greater cortisol output at 2 months (β = -0.179, p = 0.044).
Why the study?
Does low pre-operative cognitive function associate with increased post-operative inflammatory and neuroendocrine responses in patients undergoing CABG surgery?
Cohort (n=193)
Does low pre-operative cognitive function associate with increased post-operative inflammatory and neuroendocrine responses in patients undergoing CABG surgery?
Effect estimate: β = -0.212
p-value: p=0.021
Low pre-operative cognitive functioning is associated with heightened inflammatory and neuroendocrine responses following CABG surgery, suggesting a biological mechanism for poorer physical recovery.
May warrant pre-op cognitive screening to anticipate CABG inflammatory responses; leaves open causal links and clinical utility.
BACKGROUND: Cognitive functioning is linked to cardiac mortality and morbidity, but the mechanisms underlying this relationship are unclear. PURPOSE: To examine the relationship between pre-operative cognitive functioning and post-operative inflammatory and neuroendocrine responses in patients undergoing coronary artery bypass graft (CABG) surgery. METHODS: One-hundred ninety-three outpatients were screened to assess their cognitive function using the Montreal Cognitive Assessment (MoCA) on average 30 days prior to CABG surgery and provided blood samples for the measurement of interleukin (IL)-6 and C-reactive protein (CRP) and saliva samples for the measurement of diurnal cortisol. Participants were followed-up 4-8 days following surgery for the repeat measurement of IL-6 and CRP and 60 days after surgery for the measurement of diurnal salivary cortisol. RESULTS: Patients with low cognitive function (MoCA < 26) prior to surgery reached higher IL-6 concentrations in the days after surgery (β = -0.212, p = 0.021) and had greater cortisol output across the day 2 months after surgery (β = -0.179, p = 0.044). CONCLUSIONS: Low cognitive functioning is associated with a more negative pattern of biological response to surgery, indicative of poorer physical recovery. These pathways may contribute to the links between cognitive function and cardiovascular pathology.
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Poole et al. (2016) conducted a cohort in Coronary artery bypass graft (CABG) surgery (n=193). Low cognitive function (MoCA < 26) vs. Higher cognitive function was evaluated on Post-operative IL-6 concentrations (β = -0.212, p=0.021). Low pre-operative cognitive function (MoCA < 26) was associated with higher post-operative IL-6 concentrations (β = -0.212, p = 0.021) and greater cortisol output at 2 months (β = -0.179, p = 0.044).
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