Key result
Halothane produced greater negative effects on moods and symptoms and tended to produce greater negative effects on intellectual function than did isoflurane.
Why the study?
Do halothane and isoflurane anesthesia alter psychological function in healthy young men compared to unanesthetized controls?
Do halothane and isoflurane anesthesia alter psychological function in healthy young men compared to unanesthetized controls?
Halothane produces greater negative psychological effects on mood and symptoms compared to isoflurane in healthy young men.
Answers are grounded in this paper and cite their sources.
May favor isoflurane to limit mood and symptom effects; leaves open confirmation versus controls in clinical populations.
Psychological effects of halothane (16 subjects) and isoflurane (24 subjects) anesthesia on healthy young men were assessed prior to and 2,3,4,6,8, and 30 days after anesthesia. The results with each agent were compared with each other and with the results for 41 unanesthetized controls. Both agents altered psychological function. Changes in function were greatest 2 days after anesthesia; function had returned to near preanesthesia values 8 days after anesthesia. Only slight symptom and mood effects and no intellectual effect attributable to anesthesia remained 30 days after anesthesia. Halothane produced greater negative effects on moodds and symptoms and tended to produce greater negative effects on intellectural function than did isoflurane. The differences between the two anesthetics are consistent with differences in their solubilities and metabolism.
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Davison et al. (1975) studied Healthy (n=81). Halothane and Isoflurane anesthesia vs. Unanesthetized controls was evaluated on Psychological function (moods, symptoms, and intellectual function). Halothane produced greater negative effects on moods and symptoms and tended to produce greater negative effects on intellectual function than did isoflurane.
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