Key result
Blood-pressure-lowering treatment reduced the risk of stroke recurrence by 22% (p=0.0007) compared with no treatment or placebo in patients with previous cerebrovascular disease.
Why the study?
Does blood-pressure-lowering treatment reduce stroke recurrence in patients with previous cerebrovascular disease?
Population
Patients with previous cerebrovascular disease (meta-analysis of 10 trials)
Comparison
Blood-pressure-lowering treatment vs No treatment or placebo
Design
Meta-analysis
Authors
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Supports routine BP lowering for secondary stroke prevention; reinforces meta-analytic evidence and extends to diuretic regimen preference.
Meta-Analysis
Does blood-pressure-lowering treatment reduce stroke recurrence in patients with previous cerebrovascular disease?
Effect estimate: 22% reduction
p-value: p=0.0007
Blood pressure lowering significantly reduces stroke recurrence, with diuretic-based regimens appearing more effective than renin system inhibitors, likely due to greater blood pressure reduction.
Wang et al. (2010) conducted a meta-analysis in previous cerebrovascular disease. Blood-pressure-lowering treatment vs. no treatment or placebo was evaluated on stroke recurrence (22% reduction, p=0.0007). Blood-pressure-lowering treatment reduced the risk of stroke recurrence by 22% (p=0.0007) compared with no treatment or placebo in patients with previous cerebrovascular disease.
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