Key result
Parasympathetic hepatic nerve stimulation in the perfused rat liver has direct effects on glucose metabolism that are synergistic with insulin and antagonistic to glucagon.
Why the study?
Does parasympathetic nerve stimulation affect glucose metabolism in the perfused rat liver?
Population
Rat liver perfused in situ
Comparison
Perivascular nerve stimulation in the presence… vs Basal state, insulin alone, glucagon alone, or…
Design
Preclinical
Authors
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Preclinical rat liver data do not alter clinical practice; leaves open translation of neural glucose modulation to humans.
Does parasympathetic nerve stimulation affect glucose metabolism in the perfused rat liver?
Parasympathetic innervation of the rat liver directly modulates glucose metabolism, acting synergistically with insulin and antagonizing glucagon.
Gardemann et al. (1986) studied this question. Parasympathetic nerve stimulation was evaluated on Glucose and lactate metabolism. Parasympathetic hepatic nerve stimulation in the perfused rat liver has direct effects on glucose metabolism that are synergistic with insulin and antagonistic to glucagon.
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