What is the clinical evidence from this study?

Study design: Other. Population: Epilepsy or depression (n=16). Intervention: Vagus nerve stimulation (VNS) vs. VNS off. Primary outcome: Caloric intake (p=.03).

What question did this study set out to answer?

To determine how baseline body mass index and device settings influence caloric intake of palatable foods during active versus inactive vagus nerve stimulation sessions.

March 2, 2014Journal of Diabetes Science and TechnologyOpen Access

Vagus Nerve Stimulation and Food Intake

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Key result

Vagus nerve stimulation (VNS) on versus off sessions showed a significant interaction with BMI category on caloric intake (P = .03).

Why the study?

Does vagus nerve stimulation affect caloric intake in adult patients with epilepsy or depression?

Population

16 adult patients (62.5% female; BMI mean = 29.11 ± 6.65) using VNS therapy for either epilepsy or depression.

Comparison

Vagus nerve stimulation device turned on during… vs Vagus nerve stimulation device turned off during…

Design

Other

Authors

JBJamie S. BodenlosHobart and William Smith Colleges KSKristin L. SchneiderQueen Mary University of London JOJessica OleskiUniversity of Connecticut

Discussion

Member takes

Implication

Caution against BMI-based VNS adjustments; leaves open caloric intake effects for prospective validation.

Key Points

To determine how baseline body mass index and device settings influence caloric intake of palatable foods during active versus inactive vagus nerve stimulation sessions.
Tested 16 adult patients (62.5% female; mean BMI = 29.11 ± 6.65) receiving vagus nerve stimulation (VNS) for epilepsy or depression across two experimental sessions (VNS on vs. VNS off).
Measured caloric consumption by weighing four preferred snack foods totaling 1,600 calories before and after each session.
Analyzed caloric intake across BMI categories (overweight/obese vs. lean) and device parameters (output current, on time) while controlling for covariates.
A significant interaction occurred between stimulation condition (on vs. off) and BMI category regarding caloric intake (P = .03).
Device output current significantly interacted with stimulation condition to influence food consumption (P = .05).
A trend toward an interaction emerged between stimulation condition and device on time (P = .07).

Structured PICO

Does vagus nerve stimulation affect caloric intake in adult patients with epilepsy or depression?

Population

16 adult patients (62.5% female) using VNS therapy for epilepsy or depression who participated in two experimental sessions.

Intervention

Vagus nerve stimulation (VNS) device turned on during experimental session.

Comparator

Vagus nerve stimulation (VNS) device turned off during experimental session.

Outcome

Caloric intake of highly palatable foods (calculated by weighing foods before and after each session).surrogate

Main Result

p-value: p=.03

The effect of vagus nerve stimulation on caloric intake appears to be moderated by baseline BMI and device settings.

Cite This Study

Bodenlos et al. (2014) studied Epilepsy or depression (n=16). Vagus nerve stimulation (VNS) vs. VNS off was evaluated on Caloric intake (p=.03). Vagus nerve stimulation (VNS) on versus off sessions showed a significant interaction with BMI category on caloric intake (P = .03).

synapsesocial.com/papers/6a93d6cd90afb7f46c871da3 https://doi.org/10.1177/1932296814525188

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Vagus Nerve Stimulation and Food Intake

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Vagus Nerve Stimulation and Food Intake

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider