Why the study?
Handmade ePTFE-valved conduits are widely used in Japan for RVOT reconstruction due to limited homograft and bovine jugular vein availability, but their long-term outcomes and durability needed clarification independently of somatic growth.
Do large-calibre ePTFE-valved conduits provide durable long-term outcomes in patients undergoing right ventricular outflow tract reconstruction?
Population
502 patients undergoing RVOT reconstruction with ePTFE-valved conduits ≥18 mm across 34 Japanese institutions
Comparison
ePTFE-valved conduits with a diameter of ≥18 mm
Design
Multicentre cohort study
Follow-up
Up to 10 years
Key result
Large-calibre (≥18 mm) ePTFE-valved conduits for right ventricular outflow tract reconstruction showed excellent durability, with 96.6% overall survival and 89.0% freedom from explantation at 10 years.
Authors
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Supports durability of handmade ePTFE-valved conduits for large RVOT reconstructions; leaves open need for prospective comparisons with homografts.
Cohort (n=502)
Yes
Do large-calibre ePTFE-valved conduits provide durable long-term outcomes in patients undergoing right ventricular outflow tract reconstruction?
Large-calibre ePTFE-valved conduits with bulging sinuses demonstrate excellent long-term survival and freedom from explantation up to 10 years for right ventricular outflow tract reconstruction.
Fujita et al. (2020) conducted a cohort in Right ventricular outflow tract reconstruction (n=502). Large-calibre (≥18 mm) ePTFE-valved conduits was evaluated on Overall survival rate at 10 years. Large-calibre (≥18 mm) ePTFE-valved conduits for right ventricular outflow tract reconstruction showed excellent durability, with 96.6% overall survival and 89.0% freedom from explantation at 10 years.
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