Key result
HAPE was associated with significantly elevated circulating levels of endothelin-1 and decreased levels of sKDR compared to acclimatized controls or AMS.
Why the study?
Are regulators of endothelial function, circulatory homeostasis, hypoxia, and cell stress altered in climbers with AMS and HAPE compared to acclimatized controls?
Population
175 climbers in Nepal, including 71 cases of high-altitude pulmonary edema, 54 cases of acute mountain…
Design
Case-control
Authors
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Biomarker associations with HAPE severity and AMS support mechanistic studies; leaves open diagnostic or preventive utility.
Case-Control (n=175)
Are regulators of endothelial function, circulatory homeostasis, hypoxia, and cell stress altered in climbers with AMS and HAPE compared to acclimatized controls?
Biomarkers of endothelial function, vascular tone, and cell stress are altered in altitude illness, suggesting they may mechanistically contribute to the pathobiology of high-altitude pulmonary edema.
Barker et al. (2016) conducted a case-control in Acute mountain sickness (AMS) and high-altitude pulmonary edema (HAPE) (n=175). Altitude illness (HAPE and AMS) vs. Healthy acclimatized climbers was evaluated on Plasma biomarkers of endothelial function, circulatory homeostasis, hypoxia and cell stress. HAPE was associated with significantly elevated circulating levels of endothelin-1 and decreased levels of sKDR compared to acclimatized controls or AMS.