Key result
High pulmonary artery systolic pressure (≥40 mm Hg) at high altitude was associated with significantly higher NT-proBNP (137 vs 71.8; p=0.001) and BNP levels.
Why the study?
Are cardiac biomarkers (NPs, hs-cTnT) associated with high pulmonary artery systolic pressure and acute mountain sickness at high altitude?
Population
48 participants assessed post-trekking and at rest at three altitudes: 3833 m, 4450 m, and 5129 m
Design
Cohort
Authors
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NPs may aid field HAPE assessment; leaves open prospective validation before practice change.
Observational (n=48)
Are cardiac biomarkers (NPs, hs-cTnT) associated with high pulmonary artery systolic pressure and acute mountain sickness at high altitude?
Absolute Event Rate: 137% vs 71.8%
p-value: p=0.001
Natriuretic peptides and high-sensitivity troponin T are elevated at high altitude and correlate with high pulmonary artery systolic pressure and acute mountain sickness.
Mellor et al. (2014) conducted an observational in High altitude exposure (n=48). High pulmonary artery systolic pressure (≥40 mm Hg) vs. PASP <40 mm Hg was evaluated on NT-proBNP levels (p=0.001). High pulmonary artery systolic pressure (≥40 mm Hg) at high altitude was associated with significantly higher NT-proBNP (137 vs 71.8; p=0.001) and BNP levels.
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