Key result
Chronic heart failure was associated with a significantly higher frequency of nonlinear dynamics due to time irreversibility at short time scales compared to healthy subjects.
Why the study?
Does time reversibility analysis of 24-hour Holter recordings characterize differences in cardiovascular regulation between healthy subjects and chronic heart failure patients?
Population
25 subjects: 12 healthy individuals and 13 age-matched chronic heart failure patients.
Comparison
Time reversibility analysis of 24-hour Holter… vs Healthy subjects and night-time vs daytime…
Design
Cross-sectional
Follow-up
24 hours
Authors
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Time irreversibility analysis may mark autonomic dysregulation in HF; hypothesis-generating and should not yet change practice.
Observational (n=25)
Yes
Does time reversibility analysis of 24-hour Holter recordings characterize differences in cardiovascular regulation between healthy subjects and chronic heart failure patients?
p-value: p=<0.05
Time reversibility analysis of 24-hour Holter recordings can detect specific nonlinear dynamics related to autonomic regulation, which are altered in chronic heart failure patients.
Porta et al. (2009) conducted an observational in Chronic heart failure (n=25). Chronic heart failure vs. Healthy subjects was evaluated on Percentage of irreversible dynamics (IN%) at short time scales (p=<0.05). Chronic heart failure was associated with a significantly higher frequency of nonlinear dynamics due to time irreversibility at short time scales compared to healthy subjects.
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