Key result
Spontaneously hypertensive rats exhibited significant cardiac sympathovagal imbalance with increased sympathetic modulation during sleep compared to normotensive rats.
Authors
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Suggests sleep-specific sympathetic dominance in hypertensive models; leaves open relevance to human autonomic therapies.
Kuo et al. (2004) studied Spontaneous hypertension. Spontaneous hypertension (SHR strain) vs. Normotensive Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rats was evaluated on Cardiac autonomic modulations (HF, LF/HF, LF%, RR) across sleep-wake cycles. Spontaneously hypertensive rats exhibited significant cardiac sympathovagal imbalance with increased sympathetic modulation during sleep compared to normotensive rats.
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