Key result
An 8-week high-fat diet in male mice increased aortic collagen fiber deposition, MPO activity (90%), and ACE activity (28%), linking aortic stiffening to oxidative stress and RAS activation.
Population
C57BL/6 male mice
Comparison
High-fat diet for 8 weeks vs Standard diet for 8 weeks
Design
Preclinical
Follow-up
8 weeks
Authors
Loading...
Hypothesis-generating for diet-induced aortic remodeling in mice; leaves open translation to human vascular disease.
A high-fat diet induces aortic stiffening in mice, which may be associated with increased oxidative stress and activation of the renin-angiotensin system in vascular tissue.
Santana et al. (2014) studied Aortic stiffening. High-fat diet vs. Standard diet was evaluated on Aorta morphometric and biochemical measurements (collagen fibers, MPO, ACE, TGF-β). An 8-week high-fat diet in male mice increased aortic collagen fiber deposition, MPO activity (90%), and ACE activity (28%), linking aortic stiffening to oxidative stress and RAS activation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: