Key result
Obstructive sleep apnoea syndrome, present in 61.8% of ACS patients post-PCI, was associated with inflammation and increased septal thickness, but showed no significant difference in 1-year MACEs.
Why the study?
Does obstructive sleep apnoea syndrome influence clinical characteristics and major adverse cardiac events in patients with acute coronary syndrome following successful percutaneous coronary intervention?
Cohort (n=123)
Does obstructive sleep apnoea syndrome influence clinical characteristics and major adverse cardiac events in patients with acute coronary syndrome following successful percutaneous coronary intervention?
In patients with ACS undergoing successful PCI, concomitant OSAS is associated with increased inflammation and structural cardiac changes but does not significantly impact 1-year MACE rates.
No change to post-PCI ACS management indicated; leaves open questions on longer-term OSAS effects.
This study tested whether obstructive sleep apnoea syndrome (OSAS) influenced clinical characteristics and outcomes after successful percutaneous coronary intervention (PCI) in 123 consecutive patients with acute coronary syndrome (ACS). Patients with an apnoea-hypopnea index (AHI) >or= 5 were considered as having OSAS. Carotid ultrasonography and echocardiography were performed, and C-reactive protein (CRP) and fibrinogen were measured. Co-existence of ACS and OSAS occurred in 76 patients (61.8%) and patients with OSAS had a greater interventricular septum thickness (IVST) and higher levels of CRP than non-OSAS patients. In an elderly subpopulation (>or= 75 years of age), two-vessel disease was significantly more common and fibrinogen levels were significantly higher in OSAS than non-OSAS patients. Carotid intima-media thickness (IMT) correlated with the AHI in ACS patients. In elderly ACS patients, IMT, Gensini score and fibrinogen correlated with AHI. Patients were followed up for 1 year for major adverse cardiac events (MACEs) and no significant difference in major MACEs was found after this period between OASAS and non-OSAS patients. This study indicates that OSAS is associated with inflammation and increased IVST in ACS patients after successful PCI and, in elderly ACS patients, also with CAD severity and enhanced blood coagulability.
No takes yet. Share an insight, caveat, or question.
Meng et al. (2009) conducted a cohort in Acute coronary syndrome following percutaneous coronary intervention (n=123). Obstructive sleep apnoea syndrome (OSAS) vs. Non-OSAS patients was evaluated on Major adverse cardiac events (MACEs). Obstructive sleep apnoea syndrome, present in 61.8% of ACS patients post-PCI, was associated with inflammation and increased septal thickness, but showed no significant difference in 1-year MACEs.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: