Key result
Perioperative low-molecular-weight heparin was significantly associated with increased postoperative hematoma (OR 3.13; 95% CI 1.38-7.13) compared to TED stockings after breast cancer surgery.
Why the study?
Does low-molecular-weight heparin increase the risk of postoperative hematoma and sugillation compared to TED stockings in patients undergoing primary breast cancer surgery?
Population
425 patients consecutively operated on for primary breast cancer
Comparison
Low-molecular-weight heparin for perioperative… vs Thigh-long graded compression stockings
Design
Cohort
Follow-up
postoperative period
Authors
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May warrant caution with LMWH in breast cancer surgery; leaves open confirmation in randomized trials before practice change.
Cohort (n=425)
Does low-molecular-weight heparin increase the risk of postoperative hematoma and sugillation compared to TED stockings in patients undergoing primary breast cancer surgery?
Odds Ratio: 3.13 (95% CI 1.38–7.13)
In patients undergoing primary breast cancer surgery, perioperative thromboembolic prophylaxis with LMWH significantly increases the risk of postoperative hematoma and bruising compared to compression stockings.
Friis et al. (2004) conducted a cohort in Primary breast cancer (n=425). Low-molecular-weight heparin (LMWH) vs. Thigh-long graded compression (TED) stockings was evaluated on Postoperative hematoma (OR 3.13, 95% CI 1.38-7.13). Perioperative low-molecular-weight heparin was significantly associated with increased postoperative hematoma (OR 3.13; 95% CI 1.38-7.13) compared to TED stockings after breast cancer surgery.
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