January 1, 2014Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of CardiologyOpen Access

The association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: ST-elevated acute myocardial infarction (STEMI) (n=586). Intervention: Hyperuricemia (serum uric acid >6 mg/dl in women, >7 mg/dl in men) vs. Normal serum uric acid level. Primary outcome: In-hospital cardiovascular mortality (HR 5.32, 95% CI 2.46-11.49, p=0.001).

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Key result

Hyperuricemia independently predicted in-hospital cardiovascular mortality in patients with ST-elevated myocardial infarction (HR 5.32).

Why the study?

Does hyperuricemia predict in-hospital cardiovascular mortality and advanced heart failure in patients with STEMI?

Population

586 consecutive patients with ST-elevated myocardial infarction (STEMI)

Comparison

Hyperuricemia vs Normal uric acid level

Design

Cohort

Follow-up

in-hospital period

Authors

EGEmıne GazıÇanakkale Onsekiz Mart Üniversitesi

Discussion

Member takes

Implication

May refine STEMI risk stratification; leaves open whether uric acid reduction improves outcomes.

Study Design

Type

Cohort (n=586)

Structured PICO

Does hyperuricemia predict in-hospital cardiovascular mortality and advanced heart failure in patients with STEMI?

Population

586 consecutive patients with ST-elevated myocardial infarction, evaluated retrospectively during their in-hospital stay to assess the impact of admission serum uric acid levels.

Exposure

Hyperuricemia (uric acid level >6 mg/dl in women and >7 mg/dl in men)

Comparator

Normal uric acid level

Outcome

In-hospital cardiovascular mortality and advanced heart failure (class ≥ 3)hard clinical

Main Result

Hazard Ratio: 5.32 (95% CI 2.46–11.49)

Absolute Event Rate: 15.9% vs 3.1%

p-value: p=0.001

High serum uric acid levels at admission for STEMI independently predict in-hospital cardiovascular mortality and the development of advanced heart failure.

Limitations

Retrospective study design
Long-term survival and cardiac conditions could not be assessed
Majority of patients were male
Associations between inflammatory and oxidative stress markers were not evaluated
Successful thrombolytic treatment could not be evaluated

Cite This Study

Emıne Gazı (2014) conducted a cohort in ST-elevated acute myocardial infarction (STEMI) (n=586). Hyperuricemia (serum uric acid >6 mg/dl in women, >7 mg/dl in men) vs. Normal serum uric acid level was evaluated on In-hospital cardiovascular mortality (HR 5.32, 95% CI 2.46-11.49, p=0.001). Hyperuricemia independently predicted in-hospital cardiovascular mortality in patients with ST-elevated myocardial infarction (HR 5.32).

synapsesocial.com/papers/6a93e86f8dae3d6608d67d3b https://doi.org/10.5543/tkda.2014.65507

Topics

Heart failure HFrEF treatment Heart failure hospitalization

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January 1, 2014Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of CardiologyOpen Access

The association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction

View Full Paper

Ask AI

Bookmark

Key result

Hyperuricemia independently predicted in-hospital cardiovascular mortality in patients with ST-elevated myocardial infarction (HR 5.32).

Why the study?

Does hyperuricemia predict in-hospital cardiovascular mortality and advanced heart failure in patients with STEMI?

Population

586 consecutive patients with ST-elevated myocardial infarction (STEMI)

Comparison

Hyperuricemia vs Normal uric acid level

Design

Cohort

Follow-up

in-hospital period

Authors

EGEmıne GazıÇanakkale Onsekiz Mart Üniversitesi

Discussion

Member takes

Implication

May refine STEMI risk stratification; leaves open whether uric acid reduction improves outcomes.

Study Design

Type

Cohort (n=586)

Structured PICO

Does hyperuricemia predict in-hospital cardiovascular mortality and advanced heart failure in patients with STEMI?

Population

586 consecutive patients with ST-elevated myocardial infarction, evaluated retrospectively during their in-hospital stay to assess the impact of admission serum uric acid levels.

Exposure

Hyperuricemia (uric acid level >6 mg/dl in women and >7 mg/dl in men)

Comparator

Normal uric acid level

Outcome

In-hospital cardiovascular mortality and advanced heart failure (class ≥ 3)hard clinical

Main Result

Hazard Ratio: 5.32 (95% CI 2.46–11.49)

Absolute Event Rate: 15.9% vs 3.1%

p-value: p=0.001

High serum uric acid levels at admission for STEMI independently predict in-hospital cardiovascular mortality and the development of advanced heart failure.

Limitations

Retrospective study design
Long-term survival and cardiac conditions could not be assessed
Majority of patients were male
Associations between inflammatory and oxidative stress markers were not evaluated
Successful thrombolytic treatment could not be evaluated

Cite This Study

synapsesocial.com/papers/6a93e86f8dae3d6608d67d3b https://doi.org/10.5543/tkda.2014.65507

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Heart failure HFrEF treatment Heart failure hospitalization

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