Key result
Among hypertensive outpatients, amlodipine was the most prescribed drug (33.28%), and 74.07% of identified drug-drug interactions were moderate, most commonly between amlodipine and lisinopril.
Why the study?
Hypertension is a major global health problem affecting 1.13 billion people worldwide, prompting evaluation of local prescribing patterns and potential drug interactions.
Observational (n=381)
No
A high prevalence of moderate drug-drug interactions, particularly between amlodipine and lisinopril, highlights the need for careful monitoring of antihypertensive prescriptions in outpatient settings.
Local prescribing data warrant interaction audits without altering practice; leaves open need for prospective validation across settings.
Hypertension is a major problem in the world. World Health Organization (WHO) reported that 1.13 billion people in the world suffer from hypertension. This study aimed to determine antihypertensive prescription profile and drug interaction in outpatient installation at PINDAD General Hospital, Bandung in January 2019. This study was non-experimental observational studies with retrospective data collection. There were 381 patients with hypertension (50,13% female and 49,87% male). The most widely used antihypertensive drug is Amlodipine (33,28%) and Calcium Channel Blocker drug (34,20%). Moreover, we found 74,07% was moderate drug-drug interaction (DDI) with Amlodipine and Lisinopril as the most common cases (21,08%). We concluded that 15,7% prescription contain antihypertensive drugs and moderate DDI occurred in the use of amlodipine and lisinopril. DDI should get more attention due to the clinical manifestations that may occur in patients.
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Herliany et al. (2020) conducted an observational in Hypertension (n=381). Antihypertensive drug prescriptions was evaluated on Proportion of moderate drug-drug interactions among identified DDIs. Among hypertensive outpatients, amlodipine was the most prescribed drug (33.28%), and 74.07% of identified drug-drug interactions were moderate, most commonly between amlodipine and lisinopril.
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