Key result
A fixed-dose combination of amlodipine 5 mg and lisinopril 10 mg (Ekvator) provides synergetic protective effects in the treatment of arterial hypertension.
The fixed-dose combination of amlodipine and lisinopril provides synergistic protective effects in the management of arterial hypertension.
This review presents the modern views on the effectiveness of water-soluble angiotensin-converting enzyme (ACE) antagonists and calcium antagonists (CA), as monotherapy or as fixed-dose combination therapy, in the treatment of arterial hypertension (AH). The results of the X-ray structural analysis of crystal ACE-lisinopril complexes suggest a highly selective, strong inhibitory effect of lisinopril on various ACE forms of the hormonal renin-angiotensin-aldosterone system and tissue renin-angiotensin systems. The association between specific action mechanisms and therapeutic effects in hypertension is analysed for a third-generation CA amlodipine. The benefits of a fixed-dose combination medication Ekvator (amlodipine 5 mg plus lisinopril 10 mg) in hypertension are described, including its synergetic protective effects.
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Асташкин et al. (2013) conducted a review in Arterial hypertension. Ekvator (amlodipine plus lisinopril) was evaluated. A fixed-dose combination of amlodipine 5 mg and lisinopril 10 mg (Ekvator) provides synergetic protective effects in the treatment of arterial hypertension.
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