January 1, 1998Journal of Cardiovascular Pharmacology
Combination of ACE Inhibitors and Calcium Antagonists: A Logical Approach
Why the study?
Does combination therapy with ACE inhibitors and calcium antagonists provide synergistic benefits in patients with cardiovascular and renal disease?
Population
Patients with cardiovascular and renal disease, including hypertension and post-myocardial infarction left…
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
Supports mechanistic rationale for ACE inhibitor-calcium antagonist combinations; hypothesis-generating for outcome trials in cardiovascular and renal disease.
Structured PICO
Does combination therapy with ACE inhibitors and calcium antagonists provide synergistic benefits in patients with cardiovascular and renal disease?
P
Population
Patients with cardiovascular and renal disease, including hypertension and post-myocardial infarction left ventricular dysfunction
I
Intervention
Combination therapy with ACE inhibitors and calcium antagonists (e.g., verapamil and trandolapril)
The synergistic hemodynamic and vascular effects of ACE inhibitors and calcium antagonists provide a strong mechanistic rationale for their combined use in cardiovascular and renal disease.
Cite This Study
Ruschitzka et al. (1998) studied this question.