Key result
Calcium antagonists significantly inhibit coronary calcium progression over 3 years and reduce cardiovascular morbidity, but may be less effective than other antihypertensives.
Why the study?
Do calcium antagonists provide coronary benefits and reduce cardiovascular morbidity in patients with hypertension?
Population
Patients with hypertension, including those with ischemic heart disease
Comparison
Calcium antagonists vs Placebo or other types of antihypertensive drugs
Design
Review
Authors
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Should not yet change hypertension practice; leaves open comparative effectiveness versus other antihypertensives.
Do calcium antagonists provide coronary benefits and reduce cardiovascular morbidity in patients with hypertension?
Calcium antagonists offer coronary benefits through vasodilation and anti-atherosclerotic effects, but may be inferior to other antihypertensive classes for the primary prevention of ischemic heart disease.
Motro et al. (2001) conducted a review in Hypertension. Calcium antagonists vs. Placebo or other antihypertensive drugs was evaluated on Coronary calcium progression and cardiovascular morbidity/mortality. Calcium antagonists significantly inhibit coronary calcium progression over 3 years and reduce cardiovascular morbidity, but may be less effective than other antihypertensives.
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