Why the study?
Do calcium antagonists reduce cardiovascular events, stroke, heart failure, and nephropathy progression in hypertensive patients compared to other antihypertensive agents?
Population
Hypertensive patients, including those with low to moderate cardiovascular risk, stage 2 or 3 nonproteinuric…
Comparison
Calcium antagonists vs Other antihypertensive drug classes
Design
Review
Authors
Discussion
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Member takes
Implication
Calcium antagonists support stroke reduction in hypertension; leaves open optimal regimens to avert new-onset heart failure.
Structured PICO
Do calcium antagonists reduce cardiovascular events, stroke, heart failure, and nephropathy progression in hypertensive patients compared to other antihypertensive agents?
P
Population
Hypertensive patients, including those with low to moderate cardiovascular risk, stage 2 or 3 nonproteinuric kidney disease, and proteinuric kidney disease (> 300 mg protein/gram creatinine)
I
Intervention
Calcium antagonists (dihydropyridines and nondihydropyridines)
C
Comparator
Other antihypertensive drug classes
Calcium antagonists are safe and effective for blood pressure lowering and stroke reduction, but require concomitant RAAS blockade in proteinuric kidney disease and should be avoided in systolic heart failure.
Cite This Study
Nathan et al. (2005) studied this question.